Dementia is a common clinical phenomenon; however, management of the coexisting illnesses remains incomplete. Neuropsychiatric turmoil is one of the clinical characteristics of Dementia. Traditionally, this turmoil has been managed with neuroleptics or benzodiazepines but accounts serious side effects. With the advancement in the neuropharmacology field, many new-fangled medications came into existence. Donepezil is a piper dine based reversible, non-competitive cholinesterase inhibitor and proved beneficial for the management of symptoms of Alzheimer’s disease covering dementia, a disease in which cholinergic pathways in the cerebral cortex and basal forebrain are well known to be compromised.